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Revolution vs. Frontline Plus – What Is the Difference Between the Two?


  • Can be used on dogs from six weeks of age and protects against flea eggs, adult fleas, ear mites, American dog tick, heartworm, and sarcoptic mites
  • Kills grown fleas and prevents hatching of flea eggs one month; designed to prevent and control infestations (Ctenocephalides felis)
  • Treats and controls sarcoptic mange (Sarcoptes scabiei)
  • Prevents heartworm disease caused by Dirofilaria immitis
  • Treats and controls ear mite (Otodectes cynotis) problems
  • Controls tick (Dermacentor variabilis) infestations


REVOLUTION is the first FDA-approved, topically applied medication for cats that:

  • Kills grown fleas (Ctenocephalides felis) and keeps eggs from hatching
  • Prevents heartworm disease caused by Dirofilaria immitis
  • Treats and controls ear mites (Otodectes cynotis)
  • Treats and controls roundworms (Toxocara cati) and hookworms (Ancylostoma tubaeforme)

Key Features of Revolution

REVOLUTION is a medication available by prescription and is not a pesticide.

  • Active ingredient: Selamectin
  • Kills adult fleas and eggs
  • Protection from most internal and external parasites
  • Fast and easy to use
  • Non-greasy, quick-drying preparation
  • Applies in just one spot due to low-volume dosage size
  • Available in six dosage sizes in disposable, no-drip tubes
  • Can bath pet as quickly as two hours after application


REVOLUTION seeps through the skin into the bloodstream. When this product is present in the blood, it prevents and treats hookworm and roundworm infections. It distributes through the blood, into the skin and other tissues, to protect pets against ear mites, fleas, and flea eggs.

Frontline Plus:

Frontline Plus is a topical ointment applied in one location that is designed to treat and prevent ticks, fleas, and lice for cats and dogs. The primary difference in this product is it does not protect against heartworm, but it is targeted toward a larger spectrum of ticks.

Heartworm is a serious condition that is often spread by mosquitoes. It is widely common in the U.S. and has been identified in all 50 states. Treating this condition can be costly, complex, and highly involved. This makes prevention a more desirable option. If you are using Frontline Plus to prevent fleas and ticks, you will need to also use Heartgard, which is a heartworm preventive.

Revolution and Frontline Plus work quickly to help manage fleas, as well as kill the egg and adult stages of the lifecycle. However, Revolution is touted as controlling the American dog tick, while Frontline Plus is focused on the American dog tick, brown dog tick, deer ticks, and lone star tick.

We encourage pet owners living in areas where ticks are a frequent problem or where pets are outdoors more often to use Frontline Plus in conjunction with Heartgard Plus for full protection.

If you have questions, we are here to help! Please call MetroVet at 312-583-1921 to schedule an appointment to discuss flea and heartworm prevention for your pet.